Radium ra-223
Radium ra-223 is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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HCPCS
Code | Description |
|---|---|
| A9606 | Radium ra-223 dichloride, therapeutic, per microcurie |
Clinical
Clinical Trials
122 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 17 | 38 | 11 | 2 | 39 | 101 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 4 | 10 | 3 | 1 | 6 | 22 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Castration-resistant prostatic neoplasms | D064129 | — | — | 10 | 12 | 3 | — | 18 | 38 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 4 | 6 | — | — | 1 | 9 |
| Bone neoplasms | D001859 | EFO_0003820 | D16 | 3 | 7 | — | — | 1 | 9 |
| Neoplasms | D009369 | — | C80 | 3 | 3 | — | — | 3 | 8 |
| Adenocarcinoma | D000230 | — | — | 2 | 3 | — | — | 1 | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 5 | — | — | — | 5 |
| Bone marrow diseases | D001855 | — | — | 2 | 4 | — | — | — | 4 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 2 | 2 | — | — | — | 3 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 2 | — | — | — | 2 |
| Plasma cell neoplasms | D054219 | — | — | 2 | 2 | — | — | — | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urologic neoplasms | D014571 | — | C64-C68 | 1 | — | — | — | — | 1 |
| Transitional cell carcinoma | D002295 | — | — | 1 | — | — | — | — | 1 |
| Disease progression | D018450 | — | — | 1 | — | — | — | — | 1 |
| Bone diseases | D001847 | — | M89.9 | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 1 | 1 |
| Fatigue | D005221 | HP_0012378 | R53.83 | — | — | — | — | 1 | 1 |
| Male urogenital diseases | D052801 | — | — | — | — | — | — | 1 | 1 |
| Urogenital diseases | D000091642 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Radium ra-223 |
| INN | — |
| Description | Radium-223 (223Ra, Ra-223) is an isotope of radium with an 11.4-day half-life. It was discovered in 1905 by T. Godlewski, a Polish chemist from Kraków, and was historically known as actinium X (AcX). Radium-223 dichloride is an alpha particle-emitting radiotherapy drug that mimics calcium and forms complexes with hydroxyapatite at areas of increased bone turnover. The principal use of radium-223, as a radiopharmaceutical to treat metastatic cancers in bone, takes advantage of its chemical similarity to calcium, and the short range of the alpha radiation it emits.
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| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | [223Ra] |
Identifiers
| PDB | — |
| CAS-ID | 15623-45-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297420 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | — |
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Trends
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Additional graphs summarizing 58 documents
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Safety
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4,476 adverse events reported
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